Partial Coated Stem Cells with Bioinspired Silica as New Generation of Cellular Hybrid Materials

The manipulation of cell surfaces in anchorage-dependent cells can help overcome difficulties presented during handling and application. Silica-based protective mechanisms existing free-floating microorganisms may be used as inspiration for sustaining human survival suspension. Gathering on this, herein adipose-derived mesenchymal stem (hASCs) are partially coated with a hard silica layer that operates supporting platform individual Inspired by the organic templates involved biosilicification, novel chitosan (CHT) derivative displaying fully natural quaternary amine moieties is synthetized via rapid, one-pot strategy. Silicification promoted hASCs two-step process: priming step onto previously adhered this CHT derivative, followed biocompatible sol–gel process. holding backpack exhibit enhanced suspension conditions spread acquire more adherent phenotype. This new protocol cell-surface modification also provides generation hybrid materials functionalization backpack, which applied to different areas such tissue engineering, biosensing, drug delivery, targeted cell-based therapies.